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Comment & Response
March 2019

A Case for n-of-1 Trials—Reply

Author Affiliations
  • 1Department of Internal Medicine, University of California, Davis, Sacramento
  • 2Department of General Internal Medicine, University of California, San Francisco, San Francisco
  • 3Department of Psychiatry, Columbia University, New York, New York
JAMA Intern Med. 2019;179(3):453. doi:10.1001/jamainternmed.2018.7180

In Reply The letters from Vohra and Punja and Smith about our recent Original Investigation1 underscore the same crucial point: patients may vary not only in their response to treatment, but also in their response to n-of-1 trials. Vohra and Punja offer an ardent counterpoint to Mirza and Guyatt’s conclusion that n-of-1 trials are a “beautiful idea being vanquished by cruel and ugly evidence.”2(1379) Smith’s story offers an inspiring example of how n-of-1 trials may be applied informally in the service of better, more patient-centered care.

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