In Reply We thank Dr Freitag for his thoughtful comments about our Original Investigation1 regarding increased hydration for prevention of recurrent urinary tract infections (UTIs). Danone, based in France, wanted the study to be performed in Europe. It was very difficult to recruit a population of premenopausal women meeting the rigorous eligibility criteria. Thus, a feasibility study of potential sites was performed to identify research centers that had adequate resources and experience with clinical trials, quality certifications, recruitment capabilities, and interest in conducting this trial. Of 6 sites queried, only COMAC Medical in Sofia, Bulgaria, met all of these criteria and agreed to participate.
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Hooton TM, Vecchio M, Lotan Y. Delivery of Bottled Water to Women With Recurrent Urinary Tract Infections: Why in Bulgaria?—Reply. JAMA Intern Med. 2019;179(3):449. doi:10.1001/jamainternmed.2018.7977
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