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Comment & Response
March 2019

Delivery of Bottled Water to Women With Recurrent Urinary Tract Infections: Why in Bulgaria?—Reply

Author Affiliations
  • 1University of Miami Miller School of Medicine, Miami, Florida
  • 2Danone Nutricia Research, Palaiseau, France
  • 3Department of Urology, University of Texas Southwestern Medical Center, Dallas
JAMA Intern Med. 2019;179(3):449. doi:10.1001/jamainternmed.2018.7977

In Reply We thank Dr Freitag for his thoughtful comments about our Original Investigation1 regarding increased hydration for prevention of recurrent urinary tract infections (UTIs). Danone, based in France, wanted the study to be performed in Europe. It was very difficult to recruit a population of premenopausal women meeting the rigorous eligibility criteria. Thus, a feasibility study of potential sites was performed to identify research centers that had adequate resources and experience with clinical trials, quality certifications, recruitment capabilities, and interest in conducting this trial. Of 6 sites queried, only COMAC Medical in Sofia, Bulgaria, met all of these criteria and agreed to participate.

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