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Comment & Response
March 2019

Inconsistencies in Reporting Studies of Lactic Acidosis—Reply

Author Affiliations
  • 1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
  • 2Division of Nephrology, Monash Medical Centre, Clayton, Australia
  • 3Department of Medicine, Johns Hopkins University, Baltimore, Maryland
JAMA Intern Med. 2019;179(3):456. doi:10.1001/jamainternmed.2018.8594

In Reply We thank Dr de Vries for his letter and, overall, agree with his comments. Limitations of diagnostic codes exist in both studies.1,2 In the future, we believe that advancements in the design and structure of electronic health records will allow for more sophisticated algorithms to accurately identify exposures and outcomes. Such advances will be fundamental to the assessment of the risks and benefits of medications and clinical care processes, and ultimately, improvement in patient outcomes.

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