In Reply O’Neil and colleagues, of the American College of Chest Physicians (CHEST), have highlighted potential concerns in our Research Letter1 regarding financial conflicts of interest in clinical practice guidelines, which we will aim to address in this response. Through their independent review, the authors assert that both CHEST guidelines we included in our article met all 3 National Academy of Medicine (NAM) standards. To ensure accuracy, we repeated data collection for these 2 guidelines.