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Comment & Response
May 2019

Clinical Interpretation of High-Sensitivity Troponin Testing

Author Affiliations
  • 1Section of Clinical Biochemistry, University of Verona, Verona, Italy
  • 2Emergency Department, University Hospital of Parma, Parma, Italy
JAMA Intern Med. 2019;179(5):725-726. doi:10.1001/jamainternmed.2019.0371

To the Editor In a recent Special Communication published in JAMA Internal Medicine,1 Morgan and colleagues reviewed the leading causes of overuse of medical care and concluded that high-sensitivity troponin testing often yields false-positive results because a minority of patients with positive test results are finally diagnosed with myocardial infarction. We believe that this conclusion may be flawed by an incomplete appreciation of cardiac troponins biology.

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