[Skip to Navigation]
Comment & Response
June 2019

Future Directions for Corticosteroids in Treatment of Sepsis—Reply

Author Affiliations
  • 1West China Hospital, Sichuan University, Chengdu, Sichuan, China
JAMA Intern Med. 2019;179(6):845. doi:10.1001/jamainternmed.2019.0856

In Reply We are thankful for the interest shown by Spencer-Segal in our meta-analysis of corticosteroid use for treatment of sepsis.1 We welcome her thoughtful comments regarding additional directions for future trials.

First, Spencer-Segal pointed out the differences between the drugs regarding outcomes for corticosteroid use in patients with sepsis. We agree that not all corticosteroids are the same. A network meta-analysis2 concluded that methylprednisolone is less likely to result in shock reversal than hydrocortisone, though there is no clear evidence that any corticosteroid is better than another in reducing mortality.

Add or change institution