Sodium polystyrene sulfonate (sold under the brand names SPS, Kayexalate, and Kionex) is widely used for treatment of hyperkalemia. It is a synthetic cation-bound resin that exchanges sodium cations for potassium in the gastrointestinal (GI) lumen, resulting in increased fecal potassium excretion that in turn leads to decreased serum potassium levels. This drug was first introduced for treatment of hyperkalemia in 2 small uncontrolled case series in the early 1950s, and the US Food and Drug Administration (FDA) approved it for the short-term treatment of hyperkalemia in 1958.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Parks M, Grady D. Sodium Polystyrene Sulfonate for Hyperkalemia. JAMA Intern Med. Published online June 10, 2019. doi:10.1001/jamainternmed.2019.1291
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: