The United States has the largest annual number of people with new HIV diagnoses of any high-income nation in the world. In 2017, there were 38 281 people with new HIV diagnoses and 1.1 million people living with HIV.1 Men who have sex with men, African Americans, and persons living in southern US states are the most heavily affected. It is deeply disturbing that the number of new HIV diagnoses remained stable from 2012 to 2016 when effective prevention tools were available but not widely implemented.