In Reply I thank Garibaldi and Russell for their thoughtful communication and contributions to the fields of diagnosis, bedside medicine, and medical education. Indeed, the patient in my Perspective1 offers many additional lessons to those originally shared. The value of hypothesis-driven physical examination is one and is conveyed memorably in their letter. I also agree with their other assertions and recommendations. As such, I would like only to reflect further on 2 topics from this conversation.