Randomized clinical trials demonstrate that treating vitamin B12 (cobalamin, or hereinafter B12) deficiency with oral supplementation substantially increases serum B12 levels compared with intramuscular injections, with no difference in hematologic or neuropsychiatric outcomes.1 Despite this, some primary care physicians still inappropriately administer B12 injections to elderly patients.2 To our knowledge, there is no published literature characterizing prescribing patterns of intramuscular B12 using laboratory data to document patient serum levels. In this study, we assessed the prevalence of inappropriate B12 supplementation using population-based databases and estimated the associated cost.
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Silverstein WK, Lin Y, Dharma C, Croxford R, Earle CC, Cheung MC. Prevalence of Inappropriateness of Parenteral Vitamin B12 Administration in Ontario, Canada. JAMA Intern Med. Published online July 15, 2019179(10):1434–1436. doi:10.1001/jamainternmed.2019.1859
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