Recently, mirabegron, the first β3-adrenoceptor agonist, has been prescribed to treat overactive bladder (OAB) more frequently than antimuscarinic agents.1 The β-3 agonist medications have limited adverse effects compared with antimuscarinic agents.2,3 However, β3-adrenoreceptors are associated with increases in contractile force and reductions in inotropic effects,4 actions which raise concerns of cardiovascular (CV) adverse effects. These adverse effects have been reinforced by trials, finding a small increase in heart rate, blood pressure, and QTc intervals.2-4 Real-world data among older patients with CV comorbidities are lacking.5 We conducted a population-based cohort study to evaluate the risk of cardiac arrhythmias and other CV events in a population of patients 66 years and older receiving mirabegron.
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Tadrous M, Matta R, Greaves S, et al. Association of Mirabegron With the Risk of Arrhythmia in Adult Patients 66 Years or Older—A Population-Based Cohort Study. JAMA Intern Med. Published online July 15, 2019. doi:10.1001/jamainternmed.2019.2011
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