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Research Letter
Health Care Policy and Law
August 5, 2019

Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers

Author Affiliations
  • 1Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
  • 2Harvard Medical School Multi-Campus Geriatric Fellowship, Beth Israel Deaconess Medical Center, Boston, Massachusetts
  • 3Division of General Internal Medicine, Department of Medicine, Massachusetts General Hospital, Boston
JAMA Intern Med. Published online August 5, 2019. doi:10.1001/jamainternmed.2019.3107

Prescription drug spending accounts for an increasing share of US health care costs.1 Spending can be decreased by substituting generic drugs for identical brand-name drugs (generic substitution) or for brand-name drugs with similar effect (therapeutic interchange).2 We estimated the potential cost savings for Medicare from generic substitution and therapeutic interchange of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin-II-receptor blockers (ARBs).

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