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Research Letter
September 3, 2019

Association of Sodium-Glucose Cotransporter 2 Inhibitor Treatment With Risk of Hospitalization for Fournier Gangrene Among Men

Author Affiliations
  • 1Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Intern Med. Published online September 3, 2019. doi:10.1001/jamainternmed.2019.2813

Fournier gangrene—a fulminant necrosis of the fascia surrounding the genitals and perineum—is a rare and often fatal urologic emergency that disproportionally affects men at a 10:1 ratio.1 Case reports linking Fournier gangrene with the use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors prompted a US Food and Drug Administration warning in August 2018.2 We examined the association of the risk of hospitalization for Fournier gangrene with initiation of SGLT-2 inhibitor treatment among men.

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