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Comment & Response
October 2019

5α-Reductase Inhibitor Use in Patients With Prostate Cancer

Author Affiliations
  • 1Department of Urology, Fundación Santa Fe de Bogotá, Bogotá DC, Colombia
JAMA Intern Med. 2019;179(10):1439. doi:10.1001/jamainternmed.2019.3623

To the Editor The article by Sarkar and colleagues1 recently published in JAMA Internal Medicine contributes to deeper knowledge of prostate cancer diagnosis in patients who are using 5-α reductase inhibitors (5-ARIs). As noted, the prediagnostic use of 5-ARIs is associated with delayed prostate cancer diagnosis, more advanced disease, and worse prostate cancer–specific and all-cause mortality compared with nonusers who underwent prostate-specific antigen (PSA) screening.

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