[Skip to Navigation]
Views 196
Citations 0
Comment & Response
October 2019

5α-Reductase Inhibitor Use in Patients With Prostate Cancer

Author Affiliations
  • 1CHRISTUS Santa Rosa Hospital Medical Center, San Antonio, Texas
  • 2Fred Hutchinson Cancer Research Center, Seattle, Washington
  • 3Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Washington, DC
JAMA Intern Med. 2019;179(10):1440. doi:10.1001/jamainternmed.2019.3626

To the Editor Interpretation of observational studies is challenging when results are different from randomized trials.1 The recently published report by Sarkar and colleagues2 illustrates this challenge. A retrospective cohort of patients diagnosed with prostate cancer between 2001 and 2005 was described, and it was found that the use of 5-α reductase inhibitors (5-ARIs) was associated with a delayed diagnosis and a 39% increase in prostate cancer mortality. Initially, this conclusion seems at variance with the follow-up report of the randomized Prostate Cancer Prevention Trial, which showed no increase in prostate cancer mortality in men receiving finasteride compared with placebo.3

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words