[Skip to Navigation]
Comment & Response
October 2019

Studies Making Use of the Same Randomized Clinical Trial Cohorts

Author Affiliations
  • 1Basic Medical College, Department of Biochemistry and Molecular Biology, Guangxi Medical University, Nanning, Guangxi, China
JAMA Intern Med. 2019;179(10):1446-1447. doi:10.1001/jamainternmed.2019.4621

To the Editor We read the article by Smyth et al1 with interest. The authors performed a large meta-analysis to determine whether participants in large, multicenter dialysis trials were similar to the general population undergoing dialysis in terms of age, comorbidities, and mortality rate. They concluded that participants in large, multicenter randomized clinical trials of patients with end-stage kidney disease undergoing dialysis are younger, have a different pattern of comorbidities, and have a lower mortality rate than the general population of patients undergoing dialysis. This finding has implications for the generalization of trial results to the broader patient population and for future trial design. However, after carefully reading the article, we are concerned that studies making use of the same cohort of patients were included multiple times in the analysis. There were several studies described in eTable 1 in the Supplement that look quite likely to be making use of the same cohort of patients.

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words