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Comment & Response
October 2019

Studies Making Use of the Same Randomized Clinical Trial Cohorts—Reply

Author Affiliations
  • 1The George Institute for Global Health, University of New South Wales, Newtown, New South Wales, Australia
JAMA Intern Med. 2019;179(10):1447. doi:10.1001/jamainternmed.2019.4624

In Reply On behalf of my coauthors, I write to report errors in our article, “Representativeness of Randomized Clinical Trial Cohorts in End-stage Kidney Disease: A Meta-analysis,”1 that was published online in July 8, 2019, in JAMA Internal Medicine. In that article, we reported on a meta-analysis of 189 randomized clinical trials (RCTs) comprising 80 104 participants to determine whether participants in large, multicenter dialysis trials were similar to the general population undergoing dialysis in terms of age, comorbidities, and mortality rate. We found that “participants in large, multicenter RCTs of patients with end-stage kidney disease undergoing dialysis are younger, have a different pattern of comorbidities, and have a lower mortality rate than the general population of patients undergoing dialysis.”

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