The Culture of Trial Results Reporting at Academic Medical Centers

The ClinicalTrials.gov results database addresses problems with the published literature including publication bias, incomplete reporting of outcome measures and adverse events, and lack of transparency regarding the prespecified trial protocol. Submissions to ClinicalTrials.gov must contain a complete set of minimum results data elements. Entries undergo a quality-control review process based on criteria drawn from fundamental scientific principles, legal requirements, and experience operating the database.¹