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Invited Commentary
October 28, 2019

The Culture of Trial Results Reporting at Academic Medical Centers

Author Affiliations
  • 1Member of Faculty, Harvard Medical School, Cambridge, Massachusetts
  • 2Program Director, Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard, Cambridge, Massachusetts
JAMA Intern Med. Published online October 28, 2019. doi:https://doi.org/10.1001/jamainternmed.2019.4200

The ClinicalTrials.gov results database addresses problems with the published literature including publication bias, incomplete reporting of outcome measures and adverse events, and lack of transparency regarding the prespecified trial protocol. Submissions to ClinicalTrials.gov must contain a complete set of minimum results data elements. Entries undergo a quality-control review process based on criteria drawn from fundamental scientific principles, legal requirements, and experience operating the database.1

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