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Research Letter
November 4, 2019

Association Between Prescribed Opioids and Infections in Patients Neutropenia and Cancer

Author Affiliations
  • 1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I for Internal Medicine, Cologne, Germany
  • 2German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany
  • 3Institute for Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany
  • 4Department of Internal Medicine, Hematology, and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany
JAMA Intern Med. Published online November 4, 2019. doi:https://doi.org/10.1001/jamainternmed.2019.4714

In a recent article, Edelman and colleagues1 identified an association between prescribed opioids and risk for community-acquired pneumonia among patients with and without HIV infection. This is of concern for immunocompromised patients receiving opioids for cancer pain. We used the prospective Cologne Cohort of Neutropenic Patients (NCT01821456) to confirm this observation in patients with chemotherapy-induced neutropenia.

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