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Comment & Response
November 2019

Vitamin B12 Therapy in Older Adults and Misconception of Its Inappropriateness

Author Affiliations
  • 1Division of General Internal Medicine and Geriatrics, University Health Network, Sinai Health System, Toronto, Ontario, Canada
JAMA Intern Med. 2019;179(11):1606. doi:10.1001/jamainternmed.2019.4926

To the Editor We commend Silverstein and colleagues1 for examining the appropriateness of vitamin B12 therapy among older adults (study population was restricted to persons ≥65 years of age). However, we would be cautious about classifying vitamin B12 supplementation as inappropriate on the basis of either a serum B12 level below the normal limit or the absence of a serum B12 level in the 12 months prior to a prescription.1

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