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Comment & Response
January 2020

Clinical Significance and Outcomes in Trial of Nabiximols for Treatment of Cannabis Dependence

Author Affiliations
  • 1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California
  • 2Department of Psychiatry, Veterans Affairs Palo Alto Health Care System, Palo Alto, California
JAMA Intern Med. 2020;180(1):163. doi:10.1001/jamainternmed.2019.5667

To the Editor The recently published Original Investigation by Lintzeris and colleagues1 about nabiximols for the treatment of cannabis dependence reported that cannabinoid agonist medication reduces illicit cannabis use among cannabis-dependent persons. We have some concerns about how the authors represented their data, leading us to believe that such a conclusion is not justified. The authors appear to have switched primary outcomes between study registration and publication, thereby inaccurately portraying the trial results.

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