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Research Letter
February 24, 2020

Early Experience With Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement in the United States

Author Affiliations
  • 1Division of Cardiology, Department of Medicine, West Virginia University, Morgantown
  • 2Department of Cardiology, Mayo Clinic School of Medicine, Rochester, Minnesota
  • 3Center for Advanced Analytics and Informatics, Chicago, Illinois
  • 4Department of Health Systems Management, Rush University, Chicago, Illinois
JAMA Intern Med. 2020;180(5):783-784. doi:10.1001/jamainternmed.2019.6767

Despite contemporary advances in transcatheter aortic valve replacement (TAVR), procedural strokes remain a weakness of the procedure.1 Cerebral embolic protection devices (EPDs) emerged as a potential method to decrease the risk of post-TAVR strokes. However, data supporting the use of EPDs are conflicting. In the Cerebral Protection in TAVR trial, EPDs did not reduce the rate of post-TAVR stroke, although embolic debris was captured in 99% of filters.2 However, observational data and pooled analyses have suggested a potential benefit of EPDs.3,4 This study sought to evaluate the early post–US Food and Drug Administration approval experience with the Sentinel device (Boston Scientific), the only EPD available in the United States.

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