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Comment & Response
March 2020

Additional Considerations for Screening and Treatment of Depression in Patients With Acute Coronary Syndrome

Author Affiliations
  • 1Department of Emergency Medicine, School of Medicine, University of North Carolina, Chapel Hill
  • 2Department of Psychiatry, School of Medicine, University of North Carolina, Chapel Hill
  • 3Division of Cardiology, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill
JAMA Intern Med. 2020;180(3):473. doi:10.1001/jamainternmed.2019.7116

To the Editor We write regarding the randomized clinical trial conducted by Kronish et al1 that evaluated screening for depression (with and without follow-up treatment) vs no screening on outcomes (quality-adjusted life-years and depression-free days) in patients who survived an acute coronary syndrome (ACS) event. The authors did not observe a difference in outcome between the 3 study groups and concluded that systematic screening may not be justified in this population.1 Their recommendation to reconsider the clinical guidelines that advocate depression screening after cardiovascular events2 seems premature given some of the study’s limitations.

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