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Research Letter
March 16, 2020

Estimation of Glomerular Filtration Rate With vs Without Including Patient Race

Author Affiliations
  • 1Division of Nephrology, Tufts Medical Center, Boston, Massachusetts
  • 2Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts
  • 3Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
JAMA Intern Med. Published online March 16, 2020. doi:10.1001/jamainternmed.2020.0045

Glomerular filtration rate (GFR) is critically important for determining drug dosing as well as prognosis and treatment in patients with kidney disease. Despite its importance, we rarely measure it directly. Instead, we use serum creatinine level to estimate GFR (eGFRcr). Because serum creatinine is determined by diet and muscle mass as well as GFR, we use age, sex, race (African American vs non–African American), height, or weight to adjust the estimation of GFR.1-3

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