Glomerular filtration rate (GFR) is critically important for determining drug dosing as well as prognosis and treatment in patients with kidney disease. Despite its importance, we rarely measure it directly. Instead, we use serum creatinine level to estimate GFR (eGFRcr). Because serum creatinine is determined by diet and muscle mass as well as GFR, we use age, sex, race (African American vs non–African American), height, or weight to adjust the estimation of GFR.1-3
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Levey AS, Tighiouart H, Titan SM, Inker LA. Estimation of Glomerular Filtration Rate With vs Without Including Patient Race. JAMA Intern Med. Published online March 16, 2020. doi:10.1001/jamainternmed.2020.0045
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