[Skip to Content]
[Skip to Content Landing]
Views 806
Citations 0
Editor's Note
March 30, 2020

Decreasing Health Care Spending Through Market Competition—A Case for the Rapid Adoption of Adalimumab Biosimilars

Author Affiliations
  • 1Department of Internal Medicine, University of California at San Francisco, San Francisco
  • 2Editorial Fellow, JAMA Internal Medicine
  • 3Division of General Internal Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania
JAMA Intern Med. 2020;180(6):903-904. doi:10.1001/jamainternmed.2020.0331

In the Research Letter, “Shift From Adalimumab Originator to Biosimilars in Denmark,” Jensen et al1 describe the marked savings Denmark experienced after a nationwide switch from the proprietary version of adalimumab (Humira) to the biosimilar. The extent of these savings and the rapidity of the switch, even absent a substitution mandate, mirrors similar successes with other biologic biosimilar campaigns in Denmark (and some European countries). In contrast, in the US, although the Food and Drug Administration has approved biosimilars for adalimumab, they will not enter the market until 2023 owing to patent disputes with AbbVie, the manufacturer of Humira. Jensen et al1 highlight the schemes other manufacturers have taken to dissuade biosimilars from formulary inclusion in the US, including use of rebate traps. In 2013, Humira had an annual postrebate price of $19 000, which had increased to $38 000 by 2018, meaning the delay in market entry of a biosimilar has a big effect not only on increasing spending for Humira, but also increasing spending on the biosimilar, which will be priced using Humira’s price as an anchor.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words