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Comment & Response
June 8, 2020

Sex, Gender, and Precision Medicine—Reply

Author Affiliations
  • 1Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women’s Hospital, Boston, Massachusetts
  • 2Harvard Medical School, Boston, Massachusetts
  • 3Department of Psychiatry, Brigham and Women’s Hospital, Boston, Massachusetts
  • 4Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts
JAMA Intern Med. Published online June 8, 2020. doi:10.1001/jamainternmed.2020.1620

In Reply We thank Biskup and colleagues for their comments on and interest in our article.1 We agree with their assessment that while a growing body of research demonstrates wide variation between men and women in the risk, presentation, and prognosis of diseases, as well as in the response to treatment, sex and gender remain inadequately considered in medical decision-making, resulting in poorer health outcomes. We enthusiastically support the development of a community standard—much like a clinical guideline, as they suggest—as a way to improve the implementation of more precise sex- and gender-informed clinical care for every patient.

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