The 2 studies evaluating the association of recreational cannabis laws with motor vehicle crash deaths by Santaella-Tenorio et al1 and Kamer et al2 in this issue of JAMA Internal Medicine contribute to an emerging body of research necessary to inform policy on cannabis and impaired driving. Both studies use natural experiments in policy implementation to provide a high-level perspective of how legalization of recreational cannabis use may affect motor vehicle crash deaths in the population. Despite mixed findings, these studies provide much-needed research on cannabis use and driving while acknowledging that such retrospective analyses inherently lack precise control over the range of factors that can affect crashes across state populations during a period of time.