A man in his 70s with advanced prostate cancer diagnosed 6 months previously presented with progressive disease, as demonstrated by an increasing prostate-specific antigen level and worsening restaging scans, to discuss new treatment options. He reported generalized bone pain (6 out of 10 in intensity, worse with activity). His Eastern Cooperative Oncology Group performance status was 1 (scale, 0-5, with 0 = fully active and 5 = dead). Prior imaging showed no fractures. His oncologist discussed initiating therapy with oral abiraterone (CYP17A1 inhibitor, reducing androgen production). The oncologist also prescribed as-needed oxycodone instant-release 5-mg tablets, which he started taking 1 to 2 times a day.
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Saha S, Nathani P, Gupta A. Preventing Opioid-Induced Constipation: A Teachable Moment. JAMA Intern Med. 2020;180(10):1371–1372. doi:10.1001/jamainternmed.2020.3285
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