In this issue of JAMA Internal Medicine, Sacks and colleagues1 have presented an illuminating view of state regulations that either foster or inhibit the use of generic drugs instead of brand-name products. They note that the use of generic drugs has greatly reduced the aggregate cost of drugs in the US compared with what it would have been were only brand-name drugs available. To ensure that this shift continues, more needs to be done to remove poorly designed state regulations that inhibit the use of generic drugs, while at the same time ensuring that treating physicians are aware of what formulations their patients are actually receiving. In addition, pharmacists should be protected from liability when legally substituting generic drugs for brand-name products.