Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD).1,2 Based on this evidence, the US Food and Drug Administration issued a warning in December 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.3
DeGette RL, Grant RW, MPH M. Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease. JAMA Intern Med. Published online September 08, 2020. doi:10.1001/jamainternmed.2020.4191
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