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Editor's Note
September 8, 2020

Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease

Author Affiliations
  • 1University of California at San Francisco, Parnassus, San Francisco
  • 2Division of Research, Kaiser Permanente Northern California,
JAMA Intern Med. Published online September 8, 2020. doi:10.1001/jamainternmed.2020.4191

Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD).1,2 Based on this evidence, the US Food and Drug Administration issued a warning in December 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.3