Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD).1,2 Based on this evidence, the US Food and Drug Administration issued a warning in December 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.3
DeGette RL, Grant RW, MPH M. Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease. JAMA Intern Med. 2020;180(12):1605–1606. doi:10.1001/jamainternmed.2020.4191
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