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Research Letter
September 8, 2020

Representation of Older Adults in Cardiovascular Disease Trials Since the Inclusion Across the Lifespan Policy

Author Affiliations
  • 1Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina
  • 2Department of Medicine, Duke University Medical Center, Durham, North Carolina
JAMA Intern Med. Published online September 8, 2020. doi:10.1001/jamainternmed.2020.2750

Older adults traditionally have been underrepresented in cardiovascular disease (CVD) trials,1,2 requiring extrapolation of evidence from younger populations.3 In response, the National Institutes of Health (NIH) established the Inclusion Across the Lifespan Policy in January 2019 to expand representation of older adults and children in clinical research.4,5 The policy requires NIH studies to include individuals across the lifespan and to justify age-based exclusions. We set out to assess the early impact of this policy for the inclusion of older adults in CVD trials with a variety of funding sources.

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