[Skip to Navigation]
Comment & Response
September 21, 2020

Clinical Laboratory Test Unit Homogeneity—an Urgent Need

Author Affiliations
  • 1Laboratory Unit, Department of Surgical Science, School of Medicine, University of Cagliari, Cagliari, Italy
JAMA Intern Med. 2020;180(12):1715-1716. doi:10.1001/jamainternmed.2020.3532

To the Editor A recent Letter to the Editor written by Song and Zheng1 reported corrections to measurement units for a number of laboratory data previously published by Wu et al.2 Errors in measurement units are frequent in the literature; regrettably, the heterogeneity of measurement units among different commercially available analytical methods for a given biomarker is a key factor introducing an increased likelihood of errors. Several crucial issues arise from this scenario: poor accuracy in the reporting of laboratory test results by authors of clinical trials and experimental studies; poor awareness of the potential harmful consequences for patients and research results deriving from these errors (eg, misleading conclusions regarding test sensitivity and specificity); poor equivalence between published studies; poor interpretation of data collected electronically, which means the failure of electronic health record and big data collection and storage; and poor safety for patients.

Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words