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Invited Commentary
October 19, 2020

Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant

Author Affiliations
  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco
JAMA Intern Med. 2021;181(2):277-278. doi:10.1001/jamainternmed.2020.4206

In their Research Letter, Kaplan and colleagues1 report the teratogenicity of modafinil and/or armodafinil used within 6 weeks of becoming pregnant and during pregnancy based on data from the US Provigil/Nuvigil Pregnancy Registry. Of 102 prospective live births, 13% (n = 13) had major congenital malformations, a prevalence higher than the approximately 3% in the general population. Among these newborns with malformations, 4 were diagnosed with congenital torticollis, 2 with hypospadias, and 3 with congenital heart defects, yielding a cardiac malformation prevalence of 3% compared with about 1% in the general population.2

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    1 Comment for this article
    Liked to read about Modafinil and Amodafinil
    Steven James, BHMS | Steven James Neurologist
    It's a great post about Modafinil and Armdoafinil.
    CONFLICT OF INTEREST: Neurological