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Comment & Response
February 22, 2021

Caution Against Overinterpreting Time-Restricted Eating Results

Author Affiliations
  • 1Department of Emergency Medicine, Creighton University School of Medicine, Omaha, Nebraska
  • 2Division of Gastroenterology, Creighton University School of Medicine, Omaha, Nebraska
JAMA Intern Med. 2021;181(6):876-877. doi:10.1001/jamainternmed.2020.8931

To the Editor We read the randomized clinical trial from Lowe et al1 with great interest. Investigators have compared time-restricted eating (TRE, daily 16 hours fasting and 8-hour eating window) with consistent meal timing (CMT, 3 meals daily with snacking permitted) in adults with obesity. In the TRE group, noncaloric beverages were permitted outside the 8-hour eating window. The CMT group received meal coaching with daily text messages, “fruits and vegetables are healthy snacks,” “start your day with a healthy breakfast,” and “regular meals reduce snacking.”1 All the participants were instructed to measure daily weight, which were automatically uploaded from the study-provided weighing scales. The primary outcome was weight loss. Noncaloric beverages were allowed in fasting cycles in the TRE group.

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