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Comment & Response
February 22, 2021

Caution Against Overinterpreting Time-Restricted Eating Results

Author Affiliations
  • 1Department of Kinesiology and Sport Management, Texas Tech University, Lubbock
  • 2Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham
  • 3Intermountain Medical Center Heart Institute, Salt Lake City, Utah
  • 4Division of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, California
JAMA Intern Med. 2021;181(6):877-878. doi:10.1001/jamainternmed.2020.8934

To the Editor Lowe et al1 recently published a randomized clinical trial reporting that extended daily fasting, or time-restricted eating (TRE), does not improve body weight or cardiometabolic risk factors and slightly decreases appendicular lean mass, a surrogate for muscle mass. This important study is the largest published trial of TRE and suggests that TRE does not improve cardiometabolic health, or the effects may be smaller than previously reported.

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