To the Editor Lowe et al1 recently published a randomized clinical trial reporting that extended daily fasting, or time-restricted eating (TRE), does not improve body weight or cardiometabolic risk factors and slightly decreases appendicular lean mass, a surrogate for muscle mass. This important study is the largest published trial of TRE and suggests that TRE does not improve cardiometabolic health, or the effects may be smaller than previously reported.
Tinsley GM, Peterson CM, Horne BD. Caution Against Overinterpreting Time-Restricted Eating Results. JAMA Intern Med. 2021;181(6):877–878. doi:10.1001/jamainternmed.2020.8934
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