Caution Against Overinterpreting Time-Restricted Eating Results

To the Editor Lowe et al¹ recently published a randomized clinical trial reporting that extended daily fasting, or time-restricted eating (TRE), does not improve body weight or cardiometabolic risk factors and slightly decreases appendicular lean mass, a surrogate for muscle mass. This important study is the largest published trial of TRE and suggests that TRE does not improve cardiometabolic health, or the effects may be smaller than previously reported.