Recent clinical trials1,2 and a meta-analysis3 demonstrate no symptomatic benefit from treatment with levothyroxine among nonpregnant adults with subclinical hypothyroidism (defined as an elevated thyrotropin level with normal serum thyroid hormone levels). Contemporary evidence-based clinical practice guidelines strongly advise against levothyroxine supplementation for subclinical hypothyroidism.3,4 Older guidelines from professional societies generally do not recommend treatment for subclinical hypothyroidism with a thyrotropin level less than 10 mIU/L, except in special circumstances.5,6