Recent clinical trials1,2 and a meta-analysis3 demonstrate no symptomatic benefit from treatment with levothyroxine among nonpregnant adults with subclinical hypothyroidism (defined as an elevated thyrotropin level with normal serum thyroid hormone levels). Contemporary evidence-based clinical practice guidelines strongly advise against levothyroxine supplementation for subclinical hypothyroidism.3,4 Older guidelines from professional societies generally do not recommend treatment for subclinical hypothyroidism with a thyrotropin level less than 10 mIU/L, except in special circumstances.5,6
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Silverstein WK, Grady D. Overuse of Levothyroxine in Patients With Subclinical Hypothyroidism: Time to “Leve”-Out-Thyroxine. JAMA Intern Med. Published online June 21, 2021. doi:10.1001/jamainternmed.2021.2690
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