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Invited Commentary
July 19, 2021

Another Cup of Coffee Without an Arrhythmia, Please

Author Affiliations
  • 1Division of Cardiovascular Medicine, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison
  • 2Department of Internal Medicine, University of Michigan Medical School, Ann Arbor
  • 3Department of Health Management and Policy, School of Public Health, University of Michigan, Ann Arbor
  • 4Department of Veterans Health Service Research & Development Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan
JAMA Intern Med. Published online July 19, 2021. doi:10.1001/jamainternmed.2021.4073

I have measured out my life with coffee spoons…

T.S. Eliot, The Love Song of J. Alfred Prufrock, 19151

In this issue of JAMA Internal Medicine, Kim and colleagues2 investigate the association between coffee consumption and risk of tachyarrhythmia through a longitudinal prospective cohort study, coupled with a mendelian randomization analysis related to caffeine metabolism, and tests for an interaction between coffee, caffeine metabolism, and arrhythmic risk. Rhythms of interest included atrial fibrillation (AF), atrial flutter, (nonspecified) supraventricular tachycardia, ventricular tachycardia, and atrial and ventricular ectopy. The sample included nearly 400 000 select participants in UK Biobank, a unique database containing health and genetic information.

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