To the Editor Dr Buetti and colleagues provided reassuringly low rates of bloodstream infection (BSI) of less than 1 case per 10 000 peripheral intravenous catheter (PVC) regardless of removal policy.1 However, routine replacement was associated with statistically fewer PVC-BSI cases compared with clinically indicated replacement (0.005% [46 of 130 779 PVCs] vs 0.035% [15 of 281 852]). Their finding may be subject to a type 1 error and is the inverse of a meta-analysis of 9 well designed, randomized clinical trials (RCTs) that found slightly fewer PVC-BSI cases with clinically indicated replacement than with routine replacement (0.028% [1 of 3590 patients] vs 0.053% [2 of 3733 patients]).2,3