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Invited Commentary
October 23, 2023

Disentangling the Association Between Excess Thyroid Hormone and Cognition in Older Adults

Author Affiliations
  • 1Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor
  • 2Institute of Gerontology, University of Michigan, Ann Arbor
  • 3Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota
JAMA Intern Med. 2023;183(12):1332-1333. doi:10.1001/jamainternmed.2023.5618

Several large cohort studies have shown an association between exogenous thyrotoxicosis and cognitive impairment or dementia.1,2 In contrast, a recent multicohort individual participant data analysis of more than 74 000 adults did not demonstrate consistent associations between thyroid dysfunction and scores on tests of executive function, memory, or risk of dementia.3 However, while not statistically significant, individuals with overt hyperthyroidism in this study had about a 50% increased risk of dementia compared with those with normal thyroid function.

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