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Editor's Correspondence
January 9, 2006

Oxandrolone Steroid Use and Impaired Coagulation

Arch Intern Med. 2006;166(1):125. doi:10.1001/archinte.166.1.125

Anabolic, androgenic steroids have been linked with thrombotic events. Conversely, decreased coagulation has been anecdotally associated with androgens when given with warfarin. Oxandrolone is a 17α-alkylated testosterone derivative, modified to permit absorption through the gastrointestinal tract. It was approved in 1964 for osteoporotic bone pain and to facilitate weight gain after chronic infection, corticosteroid use, surgery, or trauma. It has been used off-label for AIDS-related cachexia and for the short stature of constitutional delay and Turner syndrome.