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Editor's Correspondence
October 23, 2006

Estrogen and Heart Disease: Alternatives to a Paradigm in Crisis

Arch Intern Med. 2006;166(19):2160. doi:10.1001/archinte.166.19.2160-a

Hsia et al1 conclude that neither estrogen alone nor estrogen combined with continuous medroxyprogesterone acetate provide protection against coronary heart disease in postmenopausal women in a report of the final results of the Women's Health Initiative (WHI) trial of cardioprotection by hormone therapy. They suggest that, “The views of both the medical and lay communities regarding the role of exogenous estrogen during and after menopause remain in evolution during the current paradigm shift.”1(p364)