I read with interest the article in which Qiu et al1 report that heart failure was associated with an increased risk of dementia and Alzheimer disease in a cohort of individuals 75 years or older. This relationship was offset in those receiving antihypertensive medication, 82.9% of whom were given diuretics.1 Even though the study was well designed and the results were analyzed appropriately, these findings require confirmation, since they are novel.