The article by Holmes et al1 builds logically on a framework already proposed by Stevenson et al2 with the following 3 elements common to both: understanding the person's prognosis, the initial intention of a therapy (prevention strategy), and the time until realizing benefits (or burdens). The contribution of a concept of “time until benefit” by Holmes et al1 is crucial if clinicians are to match prognosis with prescribing, while accounting for changes in people's bodies at the end of life.3
Currow DC, Abernethy AP. Frameworks for Approaching Prescribing at the End of Life. Arch Intern Med. 2006;166(21):2404. doi:10.1001/archinte.166.21.2404-a
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