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Editor's Correspondence
November 27, 2006

Sex Differences in the Benefits of the Guidelines Applied in Practice Project: Are They Due to Sex?

Arch Intern Med. 2006;166(21):2405-2406. doi:10.1001/archinte.166.21.2405-b

We read with great interest the study by Jani et al1 that examined the relative efficacy of the Guidelines Applied in Practice (GAP) program in men vs women with acute myocardial infarction.

A previous analysis of the GAP projects in Michigan demonstrated that, overall, use of the discharge tool was independently associated with a lower 1-year mortality rate (odds ratio [OR], 0.53; 95% confidence interval [CI], 0.36-0.76; P<.001).2 In the sex-specific analysis by Jani et al,1 women treated with the discharge tool had a significant reduction in 1-year mortality (OR, 0.46; 95% CI, 0.27-0.79; P = .005), while only a trend toward benefit was observed in men (OR, 0.62; 95% CI, 0.36-1.06; P = .08).