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Editor's Correspondence
January 8, 2007

Vitamin K and the Prevention of Fractures

Arch Intern Med. 2007;167(1):94. doi:10.1001/archinte.167.1.94-a

The systematic review and meta-analysis of trials by Cockayne et al1 indicates the preventive effect of vitamin K supplementation on fractures in a high-risk population. The authors analyzed the data presented in 7 trials performed in Japan, which uniformly indicated that the large daily dose of vitamin K (45 mg/d), given as menaquinone-4, for 12 to 24 months was beneficial. The synthetic vitamin used in these trials was manufactured by Eisai Co, Ltd (Tokyo, Japan).