[Skip to Content]
[Skip to Content Landing]
Editor's Correspondence
January 8, 2007

Vitamin K and the Prevention of Fractures

Author Affiliations

Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Intern Med. 2007;167(1):94. doi:10.1001/archinte.167.1.94-a

The systematic review and meta-analysis of trials by Cockayne et al1 indicates the preventive effect of vitamin K supplementation on fractures in a high-risk population. The authors analyzed the data presented in 7 trials performed in Japan, which uniformly indicated that the large daily dose of vitamin K (45 mg/d), given as menaquinone-4, for 12 to 24 months was beneficial. The synthetic vitamin used in these trials was manufactured by Eisai Co, Ltd (Tokyo, Japan).

First Page Preview View Large
First page PDF preview
First page PDF preview