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May 14, 2007

Phosphorus Comes of Age as a Cardiovascular Risk Factor

Arch Intern Med. 2007;167(9):873-874. doi:10.1001/archinte.167.9.873

Phosphorus is an important biochemical entity.1 For example, Biochemistry 101 tells us that adenosine triphosphate is the molecular currency of intracellular energy transfer; cyclic adenosine monophosphate and cyclic guanosine monophosphate are second messengers regulating many biochemical processes; addition and removal of phosphorus moieties change the catalytic activity of many enzymes; the backbones of DNA and RNA are composed of phosphorus bound to sugars; 2,3-diphosphoglycerate is a critical regulator of oxygen dissociation from hemoglobin; phosphorus is a component of important coenzymes, like nicotinamide adenine dinucleotide; and phosphorus is an integral component of structural molecules like phosphoproteins and phospholipids.