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Editor's Correspondence
July 9, 2007

Antihypertensive-Associated Incident Diabetes: Controversy Persists

Author Affiliations

Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Intern Med. 2007;167(13):1433. doi:10.1001/archinte.167.13.1433-a

The study by Barzilay et al1 reconfirms that thiazide-like diuretics are associated with an increased risk of new-onset diabetes compared with other antihypertensive agents and that incident diabetes is associated with increased risk of all cardiovascular events and significantly so for coronary heart disease. However the authors of these analyses suggest that diuretic-associated incident diabetes may be “innocent.” If true, this would be a surprising observation with important clinical implications and therefore merits careful examination.