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Editor's Correspondence
July 23, 2007

Folic Acid and Cognitive Function: What Is the Final Verdict?

Arch Intern Med. 2007;167(14):1555. doi:10.1001/archinte.167.14.1555-a

In their systematic review on pyridoxine hydrochloride (vitamin B6), cyanocobalamin or hydroxycobalamin (vitamin B12), and folic acid supplementation on cognitive function, Balk et al1(p21) concluded that

the evidence does not yet provide adequate evidence of an effect of vitamin B6 or B12 or folic acid supplementation, alone or in combination, on cognitive function testing in people with either normal or impaired cognitive function.

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