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Editor's Correspondence
July 23, 2007

Folic Acid and Cognitive Function: What Is the Final Verdict?—Reply

Author Affiliations

Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Intern Med. 2007;167(14):1555. doi:10.1001/archinte.167.14.1555-b

In reply

With the addition of the 2 recently published randomized trials of folic acid described by Naina et al, the evidence remains inconclusive, although folic acid supplementation may benefit specific populations. Even with these trials, as we reported, “firm conclusions are not possible” and the trials “do not provide adequate evidence for a beneficial effect of supplementation on cognitive function testing in people with either normal or impaired cognitive function.”1(p29)